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M94A0181.TXT
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1994-10-08
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Document 0181
DOCN M94A0181
TI Immune complex deposition in the choroid plexus of patients with
acquired immunodeficiency syndrome.
DT 9412
AU Falangola MF; Castro-Filho BG; Petito CK; Department of Pathology,
University of Miami School of Medicine,; FL 33136.
SO Ann Neurol. 1994 Sep;36(3):437-40. Unique Identifier : AIDSLINE
MED/94361475
AB We identified immune complex deposits in the choroid plexus of
approximately 75% of patients with acquired immunodeficiency syndrome
(AIDS) who had either normal brains or human immunodeficiency virus
encephalitis. Since circulating immune complexes are common in AIDS
patients, and since local choroid plexus pathology usually was absent,
their likely origin is from the bloodstream. Choroid plexus deposits of
immune complexes have been implicated in altering the function of this
structure or in enhancing its vulnerability to infection. Therefore,
immune complex deposition in the choroid plexus of AIDS patients may be
responsible for some of the common alterations in the cerebrospinal
fluid and for the frequency of opportunistic infections in this region.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY Adult
Antigen-Antibody Complex/*METABOLISM Choroid
Plexus/*IMMUNOLOGY/PATHOLOGY Female Human Male Middle Age Support,
Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).